An Endocrine Society Thematic Issue: Bone and Parathyroid Research 2024 (2024)

Marisa A Bartz-Kurycki, Sophie Dream, Tina W Yen, Kara Doffek, Joseph Shaker, Douglas B Evans, Tracy S Wang

Patients with primary hyperparathyroidism (PHPT) can present with variable signs, symptoms, and end-organ effects. Clinical practice guidelines influence referral for consideration of parathyroidectomy.

Michael J Mosca, Zhiming He, Florante R Ricarte, Carole Le Henaff, Nicola C Partridge

Teriparatide (PTH (1-34)), PTHrP (1-36), and abaloparatide (ABL) have been used for the treatment of osteoporosis, but their efficacy long term is significantly limited. The 3 peptides exert time- and dose-dependent differential responses in osteoblasts, leading us to hypothesize they...

Nipith Charoenngam, Erin Bove-Fenderson, Daniel Wong, Natalie E Cusano, Michael Mannstadt

Continuous subcutaneous infusion of recombinant parathyroid hormone (rhPTH) through a pump has been proposed as a therapeutic alternative for patients with chronic hypoparathyroidism who remain symptomatic or hypercalciuric on conventional treatment (calcium and active vitamin D) or daily injections of...

Ignacio Portales-Castillo, Abdullah Jalal, Peggy L Kendall, Deborah Parks

Approximately half of the calcium in the blood circulates in the ionized, free form; which is critical for cellular function. As a result, its levels are tightly regulated by homeostatic mechanisms dependent on hormones such as PTH, vitamin D, and...

Rola Kwayess, David S Cooper, Ghada El-Hajj Fuleihan

Various clinical manifestations of thyroiditis after parathyroidectomy have been reported in the literature, ranging from mild symptoms to tachyarrhythmias and myocardial infarction. We report 2 cases of post-parathyroidectomy thyroiditis. Both patients had primary hyperparathyroidism and underwent parathyroidectomy for a solitary...

Sylvia Ye, Vivian Grill, Jinghang Luo, Hanh H Nguyen

Denosumab-induced hypocalcemia and iron infusion–related hypophosphatemia are both well described. We describe a case of severe hypocalcemia and hypophosphatemia following sequential denosumab and parenteral iron administration. This resulted in respiratory failure due to muscle weakness and cardiac arrhythmia, requiring noninvasive...

Johan Svensson, Klara Sjögren, Lina Lawenius, Antti Koskela, Juha Tuukkanen, Karin H Nilsson, Sofia Movérare-Skrtic, Claes Ohlsson

Insulin-like growth factor-I (IGF-I) levels, which are reduced by age, and cortical bone dimensions are major determinants of fracture risk in elderly subjects. Inactivation of liver-derived circulating IGF-I results in reduced periosteal bone expansion in young and older mice. In...

Jessica Costa-Guda, Kristin Corrado, Justin Bellizzi, Elizabeth Saria, Kirsten Saucier, Miriam Guemes-Aragon, Guntas Kakar, Madison Rose, Melanie Pascal, Cynthia Alander, Sanjay M Mallya, Andrew Arnold

Primary hyperparathyroidism (PHPT) is a common endocrinopathy for which several pathogenic mechanisms, including cyclin D1 overexpression, have been identified. Vitamin D nutritional status may influence parathyroid tumorigenesis, but evidence remains circ*mstantial. To assess the potential influence of vitamin D insufficiency/deficiency...

Takuro Hakata, Yohei Ueda, Takafumi Yamash*ta, Ichiro Yamauchi, Daisuke Kosugi, Taku Sugawa, Haruka Fujita, Kentaro Okamoto, Toshihito Fujii, Daisuke Taura, Akihiro Yasoda, Haruhiko Akiyama, Nobuya Inagaki

C-type natriuretic peptide (CNP) plays a crucial role in enhancing endochondral bone growth and holds promise as a therapeutic agent for impaired skeletal growth. To overcome CNP's short half-life, we explored the potential of dampening its clearance system. Neprilysin (NEP)...

Yuhu Zhao, Xiaole Peng, Qing Wang, Zhiyu Zhang, Liangliang Wang, Yaozeng Xu, Huilin Yang, Jiaxiang Bai, Dechun Geng

The homeostasis of bone microenvironment is the foundation of bone health and comprises 2 concerted events: bone formation by osteoblasts and bone resorption by osteoclasts. In the early 21st century, leptin, an adipocytes-derived hormone, was found to affect bone homeostasis...

Natalie Y Y Koh, Justyna J Miszkiewicz, Mary Louise Fac, Natalie K Y Wee, Natalie A Sims

Preclinical models (typically ovariectomized rats and genetically altered mice) have underpinned much of what we know about skeletal biology. They have been pivotal for developing therapies for osteoporosis and monogenic skeletal conditions, including osteogenesis imperfecta, achondroplasia, hypophosphatasia, and craniodysplasias. Further...

Jing Hu, Xiaoyun Lin, Peng Gao, Qian Zhang, Bingna Zhou, Ou Wang, Yan Jiang, Weibo Xia, Xiaoping Xing, Mei Li

Mutations in WNT1 can cause rare inherited disorders such as osteogenesis imperfecta (OI) and early-onset osteoporosis (EOOP). Owing to its rarity, the clinical characteristics and pathogenic mechanism of WNT1 mutations remain unclear.

Vittoria Favero, Cristina Eller-Vainicher, Valentina Morelli, Elisa Cairoli, Antonio Stefano Salcuni, Alfredo Scillitani, Sabrina Corbetta, Silvia Della Casa, Giovanna Muscogiuri, Luca Persani, Iacopo Chiodini

The risk of vertebral fractures (VFx) in patients with adrenal incidentalomas (AI) and mild autonomous cortisol secretion (MACS) is debated.

Kirsa Skov-Jeppesen, Charlotte B Christiansen, Laura S Hansen, Johanne A Windeløv, Nora Hedbäck, Lærke S Gasbjerg, Morten Hindsø, Maria S Svane, Sten Madsbad, Jens J Holst, Mette M Rosenkilde, Bolette Hartmann

Individuals with type 2 diabetes (T2D) have an increased risk of bone fractures despite normal or increased bone mineral density. The underlying causes are not well understood but may include disturbances in the gut-bone axis, in which both glucose-dependent insulinotropic...

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